Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Itga6  integrin alpha 6   (Synonyms: 5033401O05Rik, Cd49f)
Results	Reference
1	J:165557 Ambler CA, Watt FM, Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1. Development. 2010 Nov;137(21):3569-79
1	J:94436 Barbour W, Saika S, Miyamoto T, Ohkawa K, Utsunomiya H, Ohnishi Y, Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing. Curr Eye Res. 2004 Jul;29(1):1-10
1	J:152968 Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T, Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug;17(2):175-86
1	J:329885 Belanger C, Cardinal T, Leduc E, Viger RS, Pilon N, CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms. FASEB J. 2022 Mar;36(3):e22176
1	J:276488 Bilodeau M, Shojaie S, Ackerley C, Post M, Rossant J, Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential. Stem Cell Reports. 2014 Oct 14;3(4):634-49
1	J:114702 Blanpain C, Lowry WE, Pasolli HA, Fuchs E, Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 2006 Nov 1;20(21):3022-35
1	J:49179 Brancaccio M, Cabodi S, Belkin AM, Collo G, Koteliansky VE, Tomatis D, Altruda F, Silengo L, Tarone G, Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development. Cell Adhes Commun. 1998 Mar;5(3):193-205
1*	J:36690 Buck CA, Edelman JM, Buck CE, Kennedy G, Baldwin HS, Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Cell Adhes Commun. 1996 Aug;4(2):69-87
1	J:272608 Cohen I, Zhao D, Menon G, Nakayama M, Koseki H, Zheng D, Ezhkova E, PRC1 preserves epidermal tissue integrity independently of PRC2. Genes Dev. 2019 Jan 1;33(1-2):55-60
1*	J:31111 Collo G, Domanico SZ, Klier G, Quaranta V, Gradient of integrin alpha 6A distribution in the myocardium during early heart development. Cell Adhes Commun. 1995 May;3(2):101-13
1*	J:202224 Crish J, Conti MA, Sakai T, Adelstein RS, Egelhoff TT, Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality. Dev Biol. 2013 Oct 1;382(1):136-48
1	J:306061 Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H, High proliferation and delamination during skin epidermal stratification. Nat Commun. 2021 May 28;12(1):3227
1*	J:75058 Davies D, Holley MC, Differential expression of alpha3 and alpha6 integrins in the developing mouse inner ear. J Comp Neurol. 2002 Apr 1;445(2):122-32
1	J:291945 De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyere E, Lefebvre O, Mechine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E, Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut. 2017 Oct;66(10):1748-1760
1	J:119006 de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA, Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol. 2006 Nov 20;175(4):661-70
1*	J:131286 Depreter MG, Blair NF, Gaskell TL, Nowell CS, Davern K, Pagliocca A, Stenhouse FH, Farley AM, Fraser A, Vrana J, Robertson K, Morahan G, Tomlinson SR, Blackburn CC, Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells. Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):961-6
1	J:166772 DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE, Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 2010;10:112
1	J:69569 DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO, alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol. 1997 May 5;137(3):729-42
1	J:108850 Djalilian AR, McGaughey D, Patel S, Seo EY, Yang C, Cheng J, Tomic M, Sinha S, Ishida-Yamamoto A, Segre JA, Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest. 2006 May;116(5):1243-53
1*	J:3129 Dong LJ, Chung AE, The expression of the genes for entactin, laminin A, laminin B1 and laminin B2 in murine lens morphogenesis and eye development. Differentiation. 1991 Dec;48(3):157-72
1	J:77644 Dowling J, Yu QC, Fuchs E, Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol. 1996 Jul;134(2):559-72
1	J:157054 Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S, Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis. J Invest Dermatol. 2009 Oct;129(10):2386-95
1	J:100236 Flintoff-Dye NL, Welser J, Rooney J, Scowen P, Tamowski S, Hatton W, Burkin DJ, Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn. 2005 Sep;234(1):11-21
1	J:19239 Frojdman K, Pelliniemi LJ, Differential distribution of the alpha 6 subunit of integrins in the development and sexual differentiation of the mouse testis. Differentiation. 1994 Jun;57(1):21-9
1	J:24497 Frojdman K, Pelliniemi LJ, Alpha 6 subunit of integrins in the development and sex differentiation of the mouse ovary. Dev Dyn. 1995 Apr;202(4):397-404
1	J:219824 Hendley AM, Provost E, Bailey JM, Wang YJ, Cleveland MH, Blake D, Bittman RW, Roeser JC, Maitra A, Reynolds AB, Leach SD, p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015 Mar 1;399(1):41-53
1	J:115995 Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E, Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell. 2006 Aug 11;126(3):597-609
1	J:38205 Kashimata M, Gresik EW, Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. Dev Dyn. 1997 Feb;208(2):149-61
1	J:327274 Koren E, Feldman A, Yusupova M, Kadosh A, Sedov E, Ankawa R, Yosefzon Y, Nasser W, Gerstberger S, Kimel LB, Priselac N, Brown S, Sharma S, Gorenc T, Shalom-Feuerstein R, Steller H, Shemesh T, Fuchs Y, Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis. Nat Commun. 2022 Aug 8;13(1):4628
1	J:42382 Kuster JE, Guarnieri MH, Ault JG, Flaherty L, Swiatek PJ, IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa. Mamm Genome. 1997 Sep;8(9):673-81
1	J:154054 Lange A, Wickstrom SA, Jakobson M, Zent R, Sainio K, Fassler R, Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 2009 Oct 15;461(7266):1002-6
1	J:188830 Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY, Netrin-4 activates endothelial integrin {alpha}6{beta}1. Circ Res. 2011 Sep 16;109(7):770-4
1	J:158528 Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG, Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet. 2010 Apr 15;19(8):1603-17
1	J:200273 Legate KR, Montag D, Bottcher RT, Takahashi S, Fassler R, Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Igamma in vivo. J Cell Sci. 2012 Dec 1;125(Pt 23):5636-46
1	J:274466 Li G, Ye Z, Shi C, Sun L, Han M, Zhuang Y, Xu T, Zhao S, Wu X, The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. Sci Rep. 2017 Apr 4;7:45401
1	J:193051 Marks C, Belluscio L, Ibanez CF, Critical role of GFRalpha1 in the development and function of the main olfactory system. J Neurosci. 2012 Nov 28;32(48):17306-20
1	J:199683 McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD, Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
1	J:182886 Moik DV, Janbandhu VC, Fassler R, Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci. 2011 Feb 1;124(Pt 3):414-21
1	J:272251 Noguchi S, Honda S, Saitoh T, Matsumura H, Nishimura E, Akira S, Shimizu S, Beclin 1 regulates recycling endosome and is required for skin development in mice. Commun Biol. 2019;2:37
1*	J:202041 Page ME, Lombard P, Ng F, Gottgens B, Jensen KB, The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell. 2013 Oct 3;13(4):471-82
1*	J:84372 Previtali SC, Nodari A, Taveggia C, Pardini C, Dina G, Villa A, Wrabetz L, Quattrini A, Feltri ML, Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci. 2003 Jul 2;23(13):5520-30
1	J:329047 Rodriguez UA, Dahiya S, Raymond ML, Gao C, Martins-Cargill CP, Piganelli JD, Gittes GK, Hu J, Esni F, Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation. Development. 2022 Sep 1;149(17):dev200761
1	J:131056 Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Maatta A, Watt FM, Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol. 2007 Dec 31;179(7):1599-612
1	J:94926 Shiojiri N, Sugiyama Y, Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology. 2004 Aug;40(2):346-55
1	J:69804 Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM, Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001 May 28;153(5):933-46
1*	J:157895 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H, Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science. 2010 Mar 12;327(5971):1385-9
1	J:59036 van der Neut R, Cachaco AS, Thorsteinsdottir S, Janssen H, Prins D, Bulthuis J, van der Valk M, Calafat J, Sonnenberg A, Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene. J Cell Sci. 1999 Nov;112(Pt 22):3911-22
1	J:220468 Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Potschke E, Warburton D, Qiu A, Barasch J, Purfurst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM, A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15;142(6):1125-36
1*	J:241362 Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, Renz LM, Donati G, Quist SR, Watt FM, A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells. Nat Commun. 2017 Mar 23;8:14744
1	J:105811 Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C, Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
1	J:178649 Yang DH, McKee KK, Chen ZL, Mernaugh G, Strickland S, Zent R, Yurchenco PD, Renal collecting system growth and function depend upon embryonic gamma1 laminin expression. Development. 2011 Oct;138(20):4535-44
1	J:309435 Zhang B, Tsai PC, Gonzalez-Celeiro M, Chung O, Boumard B, Perdigoto CN, Ezhkova E, Hsu YC, Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog. Genes Dev. 2016 Oct 15;30(20):2325-2338